:root{--bg:#fbfaf7;--surface:#fff;--ink:#18202b;--muted:#5a6472;--line:#e3e0d8;--accent:#1d5bbf;--accent-ink:#fff;--accent-soft:#e8effa;--warn-soft:#fbf1e3;--warn-ink:#7a4a0e;--ok-soft:#e6f3ea;--ok-ink:#1f5c34;--stop-soft:#f1eeee;--stop-ink:#6b5a5a;--chart-band:#1d5bbf29;--serif:"Iowan Old Style", "Charter", "Bitstream Charter", "Sitka Text", Cambria, Georgia, serif;--sans:system-ui, -apple-system, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;--mono:ui-monospace, "SF Mono", Menlo, Consolas, monospace;--measure:42rem;--wide:68rem;color-scheme:light dark}@media (prefers-color-scheme:dark){:root{--bg:#12161c;--surface:#1a2029;--ink:#e7e9ec;--muted:#a3acb8;--line:#2c3440;--accent:#7fb0ff;--accent-ink:#0d1420;--accent-soft:#1b2a42;--warn-soft:#3a2c17;--warn-ink:#f0c98c;--ok-soft:#173023;--ok-ink:#9ad7ac;--stop-soft:#2a2626;--stop-ink:#c9b9b9;--chart-band:#7fb0ff33}}*{box-sizing:border-box}html{-webkit-text-size-adjust:100%}body{background:var(--bg);color:var(--ink);font:1.0625rem/1.65 var(--sans);margin:0}a{color:var(--accent);text-underline-offset:.18em}a:hover{text-decoration-thickness:2px}h1,h2,h3{font-family:var(--serif);letter-spacing:-.01em;font-weight:600;line-height:1.2}h1{margin:0 0 .6rem;font-size:clamp(2rem,1.4rem + 2.6vw,3rem)}h2{margin:2.4rem 0 .6rem;font-size:1.6rem}h3{margin:1.8rem 0 .4rem;font-size:1.2rem}img,svg{max-width:100%;height:auto}.skip{position:absolute;left:-999px}.skip:focus{background:var(--surface);z-index:10;padding:.5rem 1rem;top:1rem;left:1rem}.wrap{max-width:var(--wide);margin:0 auto;padding:0 1rem}.measure{max-width:var(--measure)}.site-header{border-bottom:1px solid var(--line);background:var(--bg)}.site-header .wrap{flex-wrap:wrap;justify-content:space-between;align-items:center;gap:.5rem 1.5rem;padding-top:.9rem;padding-bottom:.9rem;display:flex}.brand{font-family:var(--serif);color:var(--ink);align-items:center;gap:.5rem;font-size:1.3rem;font-weight:700;text-decoration:none;display:inline-flex}.brand svg{width:1.6rem;height:1.6rem}.nav{flex-wrap:wrap;gap:.25rem 1.1rem;margin:0;padding:0;list-style:none;display:flex}.nav a{color:var(--ink);padding:.35rem 0;text-decoration:none;display:inline-block}.nav a:hover,.nav a[aria-current=page]{color:var(--accent);box-shadow:inset 0 -2px}main{padding:2.5rem 0 4rem}.site-footer{border-top:1px solid var(--line);color:var(--muted);font-size:.92rem}.site-footer .wrap{gap:.6rem;padding-top:1.5rem;padding-bottom:2rem;display:grid}.site-footer a{color:inherit}.lead{color:var(--muted);max-width:var(--measure);font-size:1.2rem}.meta{color:var(--muted);font-size:.92rem}.eyebrow{text-transform:uppercase;letter-spacing:.08em;color:var(--accent);margin:0 0 .4rem;font-size:.78rem;font-weight:600}.prose{max-width:var(--measure)}.prose p,.prose ul,.prose ol{margin:0 0 1.1rem}.prose li{margin:.25rem 0}.prose blockquote{border-left:3px solid var(--line);color:var(--muted);margin:1.5rem 0;padding:.2rem 0 .2rem 1.1rem}.prose code{font-family:var(--mono);font-size:.9em}.prose hr{border:0;border-top:1px solid var(--line);margin:2.5rem 0}.prose table{border-collapse:collapse;width:100%;margin:0 0 1.4rem;font-size:.95rem;display:block;overflow-x:auto}.prose th,.prose td{border-bottom:1px solid var(--line);text-align:left;vertical-align:top;padding:.5rem .6rem}.prose th{font-weight:600}.prose figure{margin:1.8rem 0}.prose figcaption{color:var(--muted);margin-top:.5rem;font-size:.9rem}.prose sup a{text-decoration:none}.prose .footnotes{color:var(--muted);font-size:.92rem}.note{background:var(--accent-soft);border-radius:10px;margin:1.5rem 0;padding:1rem 1.2rem}.note>:last-child{margin-bottom:0}.note.warn{background:var(--warn-soft)}.grid{grid-template-columns:repeat(auto-fit,minmax(16rem,1fr));gap:1rem;display:grid}.card{background:var(--surface);border:1px solid var(--line);border-radius:12px;padding:1.2rem 1.3rem}.card h3{margin-top:0}.card p{margin:.4rem 0 0}.card a.stretch{color:inherit;text-decoration:none}.card a.stretch:hover h3{color:var(--accent)}.post-list{max-width:var(--measure);gap:1.6rem;margin:0;padding:0;list-style:none;display:grid}.post-list h2,.post-list h3{margin:.1rem 0 .3rem;font-size:1.35rem}.post-list a{color:var(--ink);text-decoration:none}.post-list a:hover{color:var(--accent)}.post-list p{margin:0}.button{background:var(--accent);color:var(--accent-ink);border-radius:8px;min-height:44px;padding:.65rem 1.1rem;font-weight:600;text-decoration:none;display:inline-block}.button.secondary{color:var(--accent);box-shadow:inset 0 0 0 1.5px var(--accent);background:0 0}.chip{white-space:nowrap;border-radius:999px;padding:.12rem .55rem;font-size:.78rem;font-weight:600;display:inline-block}.chip.approved,.chip.active,.chip.running{background:var(--ok-soft);color:var(--ok-ink)}.chip.planned,.chip.preclinical{background:var(--accent-soft);color:var(--accent)}.chip.paused{background:var(--warn-soft);color:var(--warn-ink)}.chip.stopped{background:var(--stop-soft);color:var(--stop-ink)}.tracker-filters{flex-wrap:wrap;gap:.5rem;margin:1rem 0 1.5rem;display:flex}.tracker-filters a{border:1px solid var(--line);color:var(--ink);border-radius:999px;min-height:36px;padding:.35rem .85rem;text-decoration:none}.tracker-filters a:hover{border-color:var(--accent);color:var(--accent)}.tracker-filters button{font:inherit;background:var(--surface);border:1px solid var(--line);color:var(--ink);cursor:pointer;border-radius:999px;min-height:36px;padding:.35rem .85rem}.tracker-filters button:hover{border-color:var(--accent)}.tracker-filters button[aria-pressed=true]{background:var(--accent);border-color:var(--accent);color:var(--accent-ink)}.program{background:var(--surface);border:1px solid var(--line);border-radius:12px;margin:0 0 1rem;padding:1.1rem 1.3rem}.program header{flex-wrap:wrap;justify-content:space-between;align-items:baseline;gap:.3rem 1rem;display:flex}.program h3{margin:0;font-size:1.25rem}.program dl{grid-template-columns:max-content 1fr;gap:.3rem 1rem;margin:.8rem 0 0;font-size:.97rem;display:grid}.program dt{color:var(--muted)}.program dd{margin:0}.program .sources{color:var(--muted);margin:.8rem 0 0;font-size:.88rem}.program .sources a{color:var(--muted)}@media (width<=34rem){.program dl{grid-template-columns:1fr}.program dt{margin-top:.4rem}}.tags{flex-wrap:wrap;gap:.3rem;margin:.6rem 0 0;display:flex}.tag{background:var(--accent-soft);color:var(--ink);border-radius:4px;padding:.08rem .5rem;font-size:.78rem}.timeline{border-left:2px solid var(--line);max-width:var(--measure);margin:1.5rem 0;padding:0;list-style:none}.timeline li{padding:0 0 1.4rem 1.4rem;position:relative}.timeline li:before{content:"";background:var(--bg);border:2px solid var(--accent);border-radius:50%;width:12px;height:12px;position:absolute;top:.45rem;left:-7px}.timeline li.done:before{background:var(--accent)}.timeline .when{font-weight:700;font-family:var(--serif)}.timeline .tag{color:var(--muted);margin-left:.4rem;font-size:.85rem}.timeline p{margin:.2rem 0 0}.chart{background:var(--surface);border:1px solid var(--line);border-radius:12px;padding:1rem}.chart text{fill:var(--muted);font:12px var(--sans)}.chart .axis{stroke:var(--line)}.chart .zero{stroke:var(--muted);stroke-dasharray:3 3}.chart .band{fill:var(--chart-band)}.chart .line{fill:none;stroke:var(--accent);stroke-width:2.5px}.chart .marker{stroke:var(--ink);stroke-width:1.5px}.chart .label{fill:var(--ink);font-weight:600}.chart .bar-a{fill:var(--accent)}.chart .bar-b{fill:var(--muted);opacity:.55}@media (width<=34rem){.prose table{display:block;overflow:visible}.prose thead{display:none}.prose tbody,.prose tr,.prose td{width:100%;display:block}.prose tr{border-bottom:1px solid var(--line);padding:.6rem 0}.prose td{border:0;padding:.1rem 0}.prose td:first-child{font-weight:600}.prose td[data-label]:not(:first-child):before{content:attr(data-label) ": ";color:var(--muted);font-weight:600}}